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Fourth clinical research fellowship awarded
23rd January 2007
The functions of a novel B-cell specific molecule (BCNP1) in B-cell malignancies
Applicant: Professor Martin Dyer (for Dr Renata Walweska)
We have identified a novel B-cell specific protein (BCNP1) through proteomic analysis of the cell surface membrane preparations from patients with B-cell chronic lymphocytic leukaemia (B-CLL). BCNP1 is a member of an uncharacterised family of proteins. It associates with the plasma membrane via an amino-terminal pleckstrin homology domain.
Quantitative RT-PCR analysis has shown expression of BCNP1 is almost entirely B-cell specific; high level expression is seen in a variety of B-cell malignancies including CLL, follicular and mantle cell lymphomas. We are seeking to determine the functions of BCNP1. We have recently been awarded funding to allow development of specific monoclonal antibodies. We are now seeking additional funding principally to pursue gene inactivation studies both in vitro and in vivo. These studies will further our understanding of BCNP1 in normal and malignant B-cells and may allow the development of new targeted therapeutic approaches.
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