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Fifth Allison Wilson fellowship granted
1st March 2007
Role of transcriptional repressors of e-cadherin in the progression of bladder tumours
Applicant: Dr Marina Kriajevska
SNAIL/SLUG and SIP1/ZEB-1 families of transcription factors control epithelial mesenchymal transitions during embryonic development. Emerging evidence suggests that these proteins act in a number of oncogenic pathways which are responsible for the acquisition of invasive phenotype in carcinoma cells.
While the majority of these data was generated in in vitro models, the immunohistochemical analysis of the expression of these factors in tumour tissues is very limited. We accumulated preliminary data suggesting that SNAIL, SIP1 and ZEB-1 are up-regulated during bladder tumour progression. We propose i) to perform a large-scale immunohistochemical study on the expression of these factors in tumour specimens and ii) to address the function of these proteins in bladder cancer cell models.
Accomplishment of this project will allow us to examine the efficacy of SNAIL/SLUG and SIP1/ZEB-1 family members as biomarkers of invasive bladder cancer, and to assess their value as potential targets for new anti-cancer therapies.
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